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Ceefourin 1

CAS No. 315702-40-0

Ceefourin 1( —— )

Catalog No. M22241 CAS No. 315702-40-0

Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.Ceefourin 1 and Ceefourin 2, that inhibit transport of a broad range of MRP4 substrates.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Ceefourin 1
  • Note
    Research use only, not for human use.
  • Brief Description
    Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.Ceefourin 1 and Ceefourin 2, that inhibit transport of a broad range of MRP4 substrates.
  • Description
    Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.Ceefourin 1 and Ceefourin 2, that inhibit transport of a broad range of MRP4 substrates, yet are highly selective for MRP4 over other ABC transporters, including P-glycoprotein (P-gp), ABCG2 (Breast Cancer Resistance Protein;?BCRP) and MRP1 (multidrug resistance protein 1;?ABCC1).?Both compounds are more potent MRP4 inhibitors in cellular assays than the most widely used inhibitor, MK-571, requiring lower concentrations to effect a comparable level of inhibition.?Furthermore, Ceefourin 1 and Ceefourin 2 have low cellular toxicity, and high microsomal and acid stability.?
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    MRP
  • Recptor
    MRP4
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    315702-40-0
  • Formula Weight
    294.42
  • Molecular Formula
    C11H10N4S3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (424.56 mM)
  • SMILES
    S=C1N(C)C(CSC2=NC3=CC=CC=C3S2)=NN1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Cheung L , Flemming C L , Watt F , et al. High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4)[J]. Biochemical Pharmacology, 2014, 91(1):97-108.
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